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Endesfelder, D. et al. Compromised gut microbiota networks in children with anti-islet cell autoimmunity. Diabetes 63, 2006–2014 (2014). Elding Larsson, H. et al. Children followed in the TEDDY study are diagnosed with type 1 diabetes at an early stage of disease. Pediatr. Diabetes 15, 118–126 (2014).

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Palmer, C., Bik, E. M., DiGiulio, D. B., Relman, D. A. & Brown, P. O. Development of the human infant intestinal microbiota. PLoS Biol. 5, e177 (2007). Rewers, M. & Ludvigsson, J. Environmental risk factors for type 1 diabetes. Lancet 387, 2340–2348 (2016).

Ziegler, A. G. et al. Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children. J. Am. Med. Assoc. 309, 2473–2479 (2013). Jorma Toppari, Olli G. Simell, Annika Adamsson, Sanna Jokipuu, Leena Karlsson, Jukka Kero, Zhian Othmani, Petra Rajala, Eija Riski, Minna Romo, Satu Ruohonen, Satu Simell, Maija Sjöberg, Mari Vähä-Mäkilä, Sini Vainionpää, Eeva Varjonen, Jorma Ilonen, Annika Adamsson, Eeva Varjonen & Satu Simell

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA